Merck, 317642-5MG, Dipeptidylpeptidase IV Inhibitor IV, K579

Name: Dipeptidylpeptidase IV Inhibitor IV, K579
Brand: Merck
SKU: 317642-5MG

Size:5 mg, Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV, The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Catalog Number: 317642-5MG

Pricing

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Category

Protease Inhibitors

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC₅₀ = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Packaging
Packaged under inert gas
Other Notes
Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)

Specifications

General

MDL number	MFCD07364044
UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥97% (HPLC), DPP IV inhibitor, solid
Web Name Override	K579
SMILES string	N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C
InChI	1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
InChI key	JERPHRNGJBSFAP-AWEZNQCLSA-N
assay	≥97% (HPLC)
form	solid
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
color	off-white to light brown
solubility	1 M HCl: 16 mg/mL
shipped in	ambient
Quality Level	100
storage temp.	2-8°C

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Merck, 317642-5MG, Dipeptidylpeptidase IV Inhibitor IV, K579

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