Merck, 345744, Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain

General description
Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD₁b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.
M.W. 2180.5 (based on stearoyl - 18:0).
Trisialoganglioside prepared from bovine gray matter. Readily converted to GD₁b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.

Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.
For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.
Other Notes
Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)