Merck, 354R-14, TFE3 (MRQ-37) Rabbit Monoclonal Antibody

Name: TFE3 (MRQ-37) Rabbit Monoclonal Antibody
Brand: Merck
SKU: 354R-14

Size:0.1 mL

Available Catalog Numbers

354R-1000UG 354R-14 354R-15 354R-16 354R-17 354R-18 354R-200UG

Catalog Number: 354R-14

Pricing

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Category

Recombinant Antibodies

Pack Size0.1 mL

TagsClinical & Diagnostics Cell Marque™Cell Marque™ Primary Antibodies

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Xp11 translocation renal cell carcinomas (RCC) are a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus. Xp11 translocation RCC represents the most common type of RCC in children, but is less frequent on a percentage basis in adults. Morphologically, these neoplasms frequently show papillary architecture and clear cytoplasm, and frequently have associated psammoma bodies. Immunohistochemically, these neoplasms under-expresses epithelial markers such as anti-cytokeratin and anti-epithelial membrane antigen (anti-EMA) compared with typical adult type RCC. The most sensitive and specific immunohistochemical marker for the Xp11 translocation RCC is nuclear labeling of TFE3 protein, which reflects over-expression of the resulting fusion proteins relative to native TFE3. Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma of undertain differentiation. It presents in younger patients, often in the extremities. Despite relatively high rates of metastasis, patients often experience prolonged survival in the metastatic setting relative to others. The hallmark of ASPS is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an ASPSCR1-TFE3 fusion gene responsible for an aberrant transcription factor presumably enabling pathogenesis.This aberrant chimeric transcription factor retains the N-terminal DNA binding domain encoded by TFE3 while the ASPSCR1 encoded portion probably provides domain(s) modulating gene expression. The presence of this ′super-activated′ transcription factor may induce the expression of numerous molecules contributing to ASPS diagnosis, progression, and metastasis.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
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Analysis Note

IVD

RUO

Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
TFE3 Positive Control Slides, Product No. 354S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Specifications

General

NACRES	NA.41
UNSPSC Code	12352203
biological source	rabbit
conjugate	unconjugated
antibody form	culture supernatant
antibody product type	primary antibodies
clone	MRQ-37, monoclonal
description	For In Vitro Diagnostic Use in Select Regions (See Chart)
form	buffered aqueous solution
species reactivity	human
packaging	vial of 0.1 mL concentrate (354R-14)
manufacturer/tradename	Cell Marque®
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype	IgG
control	ASPS, melanoma
shipped in	wet ice
storage temp.	2-8°C
visualization	nuclear
Quality Level	100
Gene Information	human ... TFE3(7030)

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Merck, 354R-14, TFE3 (MRQ-37) Rabbit Monoclonal Antibody

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General

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