Merck, 370654-1MG, PKG Inhibitor

General description
A more specific, reversible, and substrate competitive inhibitor of protein kinase G (Ki = 86 µM) relative to protein kinase A (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).
A specific, reversible, and substrate competitive inhibitor of PKG (Ki = 86 µM) relative to PKA (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser³² to Ala³²) of histone H2B (amino acids 29-35).
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 86 µM against protein kinase G
Packaging
Yes
Other Notes
Glass, D.B., et al. 1983. Biochem. J.213, 159.
H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)