Description
General description
A peptide that selectively inhibits the activation of Gq by M₁-muscarinic cholinergic receptors. Also inhibits activation by cholecystokinin receptor in pancreatic acini at 10 µM. Blocks angiotensin II-stimulated sis-inducing factor and STAT3 tyrosine phosphorylation.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibits the activation of Gq by M1-muscarinic cholinergic receptors
Product does not compete with ATP.
Reversible: no
Other Notes
H-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH₂
Hunt, R.A., et al. 1999. Hypertension34, 603.
Tsunoda Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 648.
Mukai, H., et al. 1992. J. Biol. Chem.267, 16237.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)