Description
General description
A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]
Biochem/physiol Actions
Cell permeable: yes
Primary Target
(Hsp25) kinase
Product does not compete with ATP.
Reversible: no
Target Ki: 8.1 µM against (Hsp25) kinase
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Other Notes
H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
