Merck, 385898-50UG, Hsp90, Human

General description
Native, human Hsp90. A ~90 kDa heat shock protein that is constitutively expressed and resides in the cytoplasm. It exists as a dimer and binds to other cellular proteins such as p60v⁻src, steroid receptors, heme-regulated protein kinase, actin, and tubulin. Binds to histones with high affinity and induces chromatin condensation.
Native, human Hsp90. An ~90 kDa heat shock protein constitutively expressed and residues in the cytoplasm. It exists as a dimer and binds to other cellular proteins such as p60v⁻src, steroid receptors, heme-regulated protein kinase, actin, and tubulin. Binds to histones with high affinity and induces chromatin condensation.
Physical form
In 100 mM NaCl, 50 mM Tris-HCl, 1 mM DTT, pH 7.5.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Kim, H.R., et al. 1999. J. Biochem. 126, 1025.Schnaider, T., et al. 1999. Life Sci. 65, 2417.Welch, W.J., et al. 1982. J. Biol. Chem. 257, 14949.
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Toxicity: Standard Handling (A)