Description
General description
4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).
Biochem/physiol Actions
Primary Target
Na⁺, K⁺-ATPase activity
Product does not compete with ATP.
Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity
Physical form
Supplied at 10 mg/ml in ethanol
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
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van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Flammable (J)
