Merck, 407615-5UG, Interleukin-1β, Human, Recombinant, E. coli

General description
Recombinant, human interleukin-1β expressed in E. coli. Major form of interleukin-1 secreted by monocytes and macrophages. IL-1β is activated by proteolytic cleavage of the precursor molecule. Increases nitric oxide production in smooth muscle cells and suppresses apoptosis in rat ovarian follicles. Involved in inflammatory and immune responses and promotes wound healing. Induces nitric oxide synthase in insulin-producing cells. 1 µg of IL-1β corresponds to 1.9 x 10⁵ WHO units.
Biochem/physiol Actions
ED₅₀ = Endocrinology136, 3120.
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Symons, J.A., et al. 1987. In Lymphokines and interferons, A Practical Approach (Clemens, M.J., et al. eds.) IRL Press, Oxford p. 272.
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Disclaimer
Toxicity: Standard Handling (A)