Merck, 444218-5MG, MMP-3 Inhibitor I

General description
Inhibits matrix metalloproteinase-3 (stromelysin) (IC₅₀ = 5 µM). The inhibitor is based on a segment from the conserved region of the NH₂-terminal propeptide domain.
Inhibits the matrix metalloproteinase MMP-3 (IC₅₀ = 5 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-3
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 5 µM against MMP-3
Physical form
Supplied as a trifluroacetate salt.
Preparation Note
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for 1-2 weeks at -20°C.
Other Notes
Ac-Arg-Cys-Gly-Val-Pro-Asp-NH₂
Fotouhi, N., et al. 1994. J. Biol. Chem. 269, 30227.
Hanglow, A.C., et al. 1993. Agents Actions 39, C148.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)