Merck, 444241-5MG, MMP-2/MMP-9 Inhibitor I

General description
A potent inhibitor of MMP-2 (IC₅₀ = 310 nM) and MMP-9 (IC₅₀ = 240 nM). Orally active in animal models of tumor growth and metastasis.
A potent inhibitor of MMP-2 (gelatinase A; IC₅₀ = 310 nM) and MMP-9 (gelatinase B; IC₅₀ = 240 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-2, MMP-9
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 310 nM and 240 nM against MMP-2 and MMP-9
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)