Merck, 444249-1MG, MMP-2/MMP-9 Inhibitor II

General description
A potent inhibitor of MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
A potent inhibitor of type IV collagenases, MMP-2 (IC₅₀ = 17 nM) and MMP-9 (IC₅₀ = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 17 nM, 30 nM against MMP-2, and MMP-9, respectively
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Lauzier, M.C., et al. 2008. Mol. Pharmacol.In press.
Mifune, M., et al. 2005. J. Biol. Chem.280, 26592.
Zhang, H., et al. 2004. Circ. Res.95, 989.
Tamura, Y., et al. 1998. J. Med. Chem.41, 640.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)