Description
General description
A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).
A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
MMP-9
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 900 pM against both MMP-9 and MMP-13
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cheng, M., et al. 2000. J. Med. Chem.43, 369.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
