Merck, 444288-5MG, MMP-2 Inhibitor III

General description
A cell-permeable biphenylsulfonamido-hydroxamate compound that acts a potent and Zn²⁺-binding site-targeting inhibitor of MMP-2 (IC₅₀ = 12 nM). It exhibits good selectivity over MMP-9 and MMP-3 (IC₅₀ = 0.2 and 4.5 µM, respectively) and shows practically no effect towards MMP-1 and MMP-7 (IC₅₀ >50 µM). Shown to effectively suppress the invasiveness of HT1080 sarcoma cells grown on matrigel.
Biochem/physiol Actions
Target IC₅₀: 12 nM against MMP-2
Cell permeable: yes
Primary Target
MMP-2
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Tuccinardi, T., et al. 2006. Bioorg. Med. Chem.14, 4260.
Rossello, A., et al. 2004. Bioorg. Med. Chem.12, 2441.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)