Merck, 50937-100ML, Guanidine hydrochloride solution

Name: Guanidine hydrochloride solution
Brand: Merck
SKU: 50937-100ML

Size:100 mL, Aminoformamidine hydrochloride, Guanidinium chloride, Guanidium chloride, BioUltra, ~8 M in H₂O

Catalog Number: 50937-100ML

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Category

Ionic Detergents

Pack Size100 mL

TagsChemistry & Biochemicals Biochemicals Detergents

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Guanidine hydrochloride solution has been used as a fixation buffer in genomic DNA extraction for genomic analysis.
Biochem/physiol Actions
Guanidine‐HCl (Gnd-HCl), an efficient chaotropic agent, is broadly used in RNA isolation, globular protein denaturation, and protein refolding studies as a denaturant. It is an appropriate sample buffer for the quick and effective elution of affinity-purified protein complexes and the subsequent protein digestion step. Gnd-HCl is not preferred in proteomics experiments due to its hindrance with trypsin activity at low molar concentrations and tendency to precipitate when combined with sodium dodecyl sulfate (SDS). GnHCl is commonly utilized to extract proteins in extracellular matrix (ECM)‐rich tissues including bone, cartilage, ligament, and tendon.

Specifications

General

UNSPSC Code	12352107
NACRES	NA.25
PubChem Substance ID	57651286
MDL number	MFCD00013026
Beilstein/REAXYS Number	3591990
InChI	1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
SMILES string	Cl.NC(N)=N
InChI key	PJJJBBJSCAKJQF-UHFFFAOYSA-N
product line	BioUltra
form	liquid
concentration	~8 M in H2O
impurities	insoluble matter, passes filter test
refractive index	n20/D 1.465
pH	4.5-7.5 (25 °C)
anion traces	sulfate (SO42-): ≤50 mg/kg
cation traces	Al: ≤1 mg/kg
<i>λ</i>	neat
UV absorption	λ: 260 nm Amax: 0.040
Gene Information	human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)

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Merck, 50937-100ML, Guanidine hydrochloride solution

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General

Notice

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