Merck, 528906-10MG, Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded

General description
Hypochromicity: ≥40% at 248 nm.
Known to induce interferon production.
Application

Penaeus monodon Interferon Regulatory Factor (PmIRF) Activates IFNs and Antimicrobial Peptide Expression via a STING-Dependent DNA Sensing Pathway.: This study explores the role of PmIRF in shrimp immune responses, specifically how it activates interferons and antimicrobial peptides through the STING-dependent DNA sensing pathway, enhancing antiviral defenses. (Soponpong et al., 2021).

Identification, expression profiling of a grass carp TLR8 and its inhibition leading to the resistance to reovirus in CIK cells.: This article focuses on the TLR8 receptor in grass carp, its expression profiles, and how its inhibition confers resistance to reovirus in fish cell lines, providing insights into antiviral immunity in aquatic species. (Chen et al., 2013).

Identification and expression profiles of ADAR1 gene, responsible for RNA editing, in responses to dsRNA and GCRV challenge in grass carp (Ctenopharyngodon idella).: The study examines the ADAR1 gene involved in RNA editing in grass carp, highlighting its response to double-stranded RNA and grass carp reovirus, shedding light on fish immune mechanisms. (Yang et al., 2012).

Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice.: This research differentiates the effects of hydrodynamic treatment and naked siRNA delivery in mice, showing that immune activation and organ damage are associated with the treatment method rather than the siRNAs themselves. (Rácz et al., 2011).

Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)