Merck, 539211-50MG, Protein Methyltransferase Inhibitor, AMI-5

Name: Protein Methyltransferase Inhibitor, AMI-5
Brand: Merck
SKU: 539211-50MG

Size:50 mg, Protein Methyltransferase Inhibitor, AMI-5, Disodium-2-(2, 4, 5, 7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III, The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Catalog Number: 539211-50MG

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Category

Protease Inhibitors

Pack Size50 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC₅₀ against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2).

Packaging
Packaged under inert gas
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)

Specifications

General

UNSPSC Code	12171500
NACRES	NA.54
MDL number	MFCD00005040
SMILES string	[Na+].[Na+].Brc1c2[o][c]3[c](c(c2cc([c]1=O)Br)c4c(cccc4)C(=O)[O-])=CC(=C(C=3Br)[O-])Br
InChI	1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChI key	SEACYXSIPDVVMV-UHFFFAOYSA-L
assay	≥90%
form	solid
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
color	red-brown
solubility	water: 50 mg/mL
shipped in	ambient
Quality Level	100
storage temp.	2-8°C

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Merck, 539211-50MG, Protein Methyltransferase Inhibitor, AMI-5

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