Merck, 539522-5MG, PKCε Translocation Inhibitor Peptide

General description
An octapeptide that selectively inhibits the translocation of protein kinase Cε to subcellular sites in a reversible manner. Inhibition of PKCεtranslocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
PKCε Translocation
Product does not compete with ATP.
Reversible: yes
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.
Other Notes
H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH
Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.
Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.
Legal Information
Sold under license of U.S. Patent 5,783,405.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)