Merck, 539695-10MG, PME-1 Inhibitor, AMZ-30

General description
A cell-permeable sulfonyl acrylonitrile compound that acts as a potentand irreversible inhibitor of protein phosphatase methylesterase-1(PME-1; IC₅₀ = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)