Merck, 56690-1MG, Hypericin from Hypericum perforatum

General description
Hypericin hydrophobic is a red color pigment occurring naturally in Hypericum perforatum. Its fluorescence is measured at 600 nm. It is localized in the intracellular membranes including nuclear membrane, mitochondrial membrane, Golgi apparatus, lysosomes and endoplasmic reticulum.
Application
Hypericin from Hypericum perforatum has been used:
in the broth macrodilution test and antibacterial assay against bacterial strains
as a medium supplement for human malignant melanoma cells for irradiation and localization studies
as a ligand for pregnane X receptor (PXR) and as defatting medium supplement for primary human hepatocytes culture

Biochem/physiol Actions
Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria.
Hypericin is a potent inhibitor of protein kinase C (PKC), telomerase, cytochrome P450 and reverse transcriptase. It is exploited for its photosensitizing functionality in photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in cancer cells.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.