Merck, 569251-U, Discovery® HS C18 HPLC Column

Name: Discovery® HS C18 HPLC Column
Brand: Merck
SKU: 569251-U

Size:1 ea, Discovery RP18 HPLC Column, 3 μm particle size, L × I.D. 7.5 cm × 4.6 mm

Catalog Number: 569251-U

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Category

Reversed-Phase HPLC Columns

Pack Size1 ea

TagsHPLC Columns Analytical Chemistry Analytical Chromatography

CollectionsMerck Analytical Chromatography Products & Lab Supplies Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Discovery® HS C18 HPLC column (L × I.D. 7.5 cm × 4.6 mm) is generally found to be stable under acidic and basic conditions.
Application

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research demonstrates the use of the Discovery® HS C18 HPLC Column in developing a robust HPLC method for analyzing molnupiravir, showcasing its importance in current pandemic-related pharmaceutical research (Recber et al., 2022).

A new RP-HPLC method as an auxiliary tool for optimization of sample preparation procedures for tracing of PPCPs of different hydrophilicities.: Highlights the adaptability of the Discovery® HS C18 HPLC Column in environmental monitoring, specifically for pharmaceutical and personal care products, enhancing analytical methods for environmental safety (Portillo-Castillo et al., 2021).

Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: This study uses the Discovery® HS C18 HPLC Column to assess terizidone levels in patient plasma, providing critical insights into the treatment of drug-resistant tuberculosis (Mulubwa and Mugabo, 2018).

Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: Depicts the utility of the Discovery® HS C18 HPLC Column in optimizing liquid chromatography methods for the potent chemotherapeutic agent doxorubicin, underscoring its role in therapeutic drug monitoring (Maliszewska et al., 2018).

Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: Showcases the Discovery® HS C18 HPLC Column′s application in studying the permeability and transport of efavirenz across the placenta, providing valuable pharmacological insights (Zelena et al., 2017).

Features and Benefits
Stable, low bleed for LC-MS applications
Scalable from analytical to preparatory
Highly stable to ensure excellent run-to-run and lot-to-lot reproducibility
Higher hydrophobicity for better resolution of difficult analytes

Other Notes
Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Specifications

General

UNSPSC Code	41115700
eCl@ss	32110501
Web Name Suffix Override	L × I.D. 7.5 cm × 4.6 mm, HPLC Column
Web Name Override	Discovery® HS C18 (3 µm) HPLC Columns
NACRES	SB.52
material	stainless steel column
agency	suitable for USP L1
product line	Discovery®
feature	endcapped
manufacturer/tradename	Discovery®
packaging	1 ea of
extent of labeling	20% Carbon loading
parameter	≤70 °C temp. range
technique(s)	HPLC: suitable
L × I.D.	7.5 cm × 4.6 mm
surface area	300 m2/g
surface coverage	3.2 μmol/m2
impurities	<10 ppm metals
matrix	silica gel, high purity, spherical particle platform
matrix active group	C18 (octadecyl) phase
particle size	3 μm
pore size	120 Å
operating pH range	2-8
application(s)	food and beverages
separation technique	reversed phase

FAQs

Question: What are the column dimensions?

Answer:The column is 4.6 mm ID × 75 mm long.

Question: What particle size and phase are used?

Answer:It uses 3 µm fully porous silica with an endcapped C18 phase.

Question: What is the maximum pressure rating?

Answer:The column is rated to 400 bar.

Application Note

Discovery® HS C18 is a high-purity silica reversed-phase HPLC column designed for robust separation of a broad range of analytes. This configuration uses 3 µm fully porous particles in a 4.6 × 75 mm stainless-steel column. The C18 phase is endcapped, has 120 Å pores, approximately 20% carbon loading, and an operating pH range of about 2–8. The column is rated to 400 bar and temperatures up to approximately 70 °C. Its high-purity silica and dense bonded phase support reproducible reversed-phase separations for pharmaceutical, food, environmental, and general analytical applications. The short 75 mm format provides relatively fast analyses while maintaining the selectivity of the Discovery HS C18 phase.

Ordering

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