Merck, 569252-U, Discovery® HS C18 HPLC Column

Name: Discovery® HS C18 HPLC Column
Brand: Merck
SKU: 569252-U

Size:1 ea, Discovery RP18 HPLC Column, 3 μm particle size, L × I.D. 15 cm × 4.6 mm

Catalog Number: 569252-U

Pricing

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Category

Reversed-Phase HPLC Columns

Pack Size1 ea

TagsHPLC Columns Analytical Chemistry Analytical Chromatography

CollectionsMerck Analytical Chromatography Products & Lab Supplies Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This research developed a robust RP-HPLC method for the quantitative analysis of molnupiravir, a COVID-19 therapeutic, utilizing nanoformulations. The study highlights the method′s stability and effectiveness in permeability studies, demonstrating its potential in pharmaceutical analysis (Reçber et al., 2022).

Analysis of terizidone in plasma using HPLC-UV method and its application in a pharmacokinetic study of patients with drug-resistant tuberculosis.: The study developed and validated an HPLC-UV method for analyzing terizidone in plasma, essential for pharmacokinetic studies in patients with drug-resistant tuberculosis. The method′s reliability supports its use in clinical and pharmacological research (Mulubwa and Mugabo, 2018).

Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.: This research focuses on optimizing a liquid chromatography method to quantify doxorubicin in plasma and urine. It is crucial for pharmacokinetic, biomedical, and drug monitoring studies, ensuring accurate and precise therapeutic monitoring (Maliszewska et al., 2018).

Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV.: This study introduces a universal HPLC-UV method for determining efavirenz in various biological matrices, including transport studies, rat placenta perfusion, and lysate. It is significant for pharmacokinetic and drug distribution research (Zelena et al., 2017).

Features and Benefits
Stable, low bleed for LC-MS applications
Scalable from analytical to preparatory
Highly stable to ensure excellent run-to-run and lot-to-lot reproducibility
Higher hydrophobicity for better resolution of difficult analytes

Other Notes
Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Specifications

General

UNSPSC Code	41115700
eCl@ss	32110501
Web Name Suffix Override	L × I.D. 15 cm × 4.6 mm, HPLC Column
Web Name Override	Discovery® HS C18 (3 µm) HPLC Columns
NACRES	SB.52
material	stainless steel column
agency	suitable for USP L1
product line	Discovery®
feature	endcapped
manufacturer/tradename	Discovery®
packaging	1 ea of
extent of labeling	20% Carbon loading
parameter	≤70 °C temp. range
technique(s)	HPLC: suitable
L × I.D.	15 cm × 4.6 mm
surface area	300 m2/g
surface coverage	3.2 μmol/m2
impurities	<10 ppm metals
matrix	silica gel, high purity, spherical particle platform
matrix active group	C18 (octadecyl) phase
particle size	3 μm
pore size	120 Å
operating pH range	2-8
application(s)	food and beverages
separation technique	reversed phase

FAQs

Question: What are the dimensions of this Discovery HS C18 column?

Answer:The column is 15 cm long with a 4.6 mm internal diameter.

Question: What particle and pore sizes are used?

Answer:It contains 3 µm fully porous particles with 120 Å pores.

Question: What is the stationary phase?

Answer:It uses an endcapped C18 phase with approximately 20% carbon loading.

Application Note

Discovery® HS C18 HPLC Column is used for high-performance reversed-phase separation of small molecules when strong hydrophobic retention, reproducible peak shape and LC-MS compatibility are required. This configuration measures 15 cm × 4.6 mm and contains 3 µm fully porous high-purity silica particles with 120 Å pores. The endcapped C18 stationary phase carries approximately 20% carbon loading and is classified as USP L1. The column operates over a stated pH range of 2–8, supports pressures up to 400 bar and can be used at temperatures up to approximately 70°C. The smaller 3 µm particles provide higher efficiency than conventional 5 µm formats while retaining standard HPLC hardware dimensions. It is suitable for pharmaceutical, food, environmental and other analytical workflows requiring robust reversed-phase selectivity.

Ordering

Notice

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