Merck, 575608-U, Discovery® DSC-Si SPE 96-well Plate

General description
Retention Mechanism: Normal phase
Sample Matrix Compatibility: Organic solvents, oils, and lipids

Unbonded acid washed silica sorbent ideal for normal phase SPE and other modified flash techniques
Often used to separate or remove structurally similar molecules through successive elutions with increasingly polar solutions
The most polar normal phase sorbent available
Excellent capacity for purifying solution phase combinatorial chemistry reactions when removing target molecules from reaction by-products and excess reagents
Available in Büchner Funnel configurations for easy scalability

Application

High-Throughput Mass Spectrometry for Biopharma: Utilizes the Discovery DSC-Si SPE 96-well plate for rapid and accurate biomolecule characterization, demonstrating its critical role in high-throughput analytical setups, enhancing productivity in biopharmaceutical analysis (Campuzano et al., 2022).

Towards a Point-of-Care Diagnostic Platform for Multiplex Sensing: Highlights the application of Discovery DSC-Si SPE 96-well plates in developing advanced diagnostic platforms, specifically for detecting mild traumatic brain injury biomarkers, showcasing the plate′s versatility and reliability in clinical settings (Jović et al., 2022).

Determination of Crizotinib in Plasma by LC-ESI-MS/MS: Demonstrates the use of Discovery DSC-Si SPE 96-well plates in pharmacokinetic studies, providing robust and efficient sample preparation methods for therapeutic drug monitoring and clinical research (Roberts et al., 2014).

High-throughput Mass Spectrometric Cytochrome P450 Inhibition Screening: Applies the Discovery DSC-Si SPE 96-well plate in drug metabolism studies, specifically in the screening of cytochrome P450 enzyme inhibitors, which is crucial for predicting drug-drug interactions in drug development (Lim et al., 2013).

Development of a High-Throughput SPE/MS Method for Cytochrome P450 Inhibition: Uses the Discovery DSC-Si SPE 96-well plate to enhance throughput in the pharmacological screening of drug candidates, underscoring its importance in the early stages of drug discovery to assess potential toxicities (Lim et al., 2010).

Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany