Merck, 662056-50UG, Ubiquitin Aldehyde

General description
Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.
Biochem/physiol Actions
Primary Target
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Shown to inhibit the activity of Isopeptidase T (Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (Cat. No. 662090)
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 150 mM HCL.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C).
Other Notes
Melandri, F., et al. 1996. Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)