Merck, 791056P-1G, 2-OHOA

General description
2-hydroxyoleic acid (2-OHOA) is a synthetic and non-β oxidation-metabolizable oleic acid derivative. It contains 18 carbon atoms in its fatty acid chain length.
Application
2-hydroxyoleic acid (2-OHOA) is suitable for use:
to study its antihypertensive action in adult spontaneously hypertensive rats (SHRs)
to study the chemical structure-effect relation of 2-OHOA in the reduction of body weight in rats
as an antitumor compound, to study its effect on xenografts lipidome based on imaging mass spectrometry (IMS)

Biochem/physiol Actions
2-Hydroxy Oleic Acid is an inducer of cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2-Hydroxy Oleic Acid increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
2-hydroxyoleic acid (2-OHOA) acts as a potential antihypertensive agent. Oral administration of 2-OHOA is used to reduce body weight.
Packaging
20 mL Clear Glass Screw Cap Vial (791056P-1g)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC