Merck, 791275P-5MG, 18:0 PE-DTPA (Gd)

General description
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.
Application
18:0 PE-DTPA (Gd) has been used:
as a component of Gadolinium-liposome preparation
in the nanodics preparation for nuclear magnetic resonance (NMR) studies
in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies

Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.
Packaging
5 mL Amber Glass Screw Cap Vial (791275P-5mg)
Legal Information
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