Merck, 791641C-1MG, 15:0-18:1-d7-PI

General description
15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol) is a deuterated phospholipid. The lipid comprises the phosphotidylinositol attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phosphotidylinositol are esterified inositol associated with bacteria and eukaryotes. It is synthesized in endoplasmic reticulum and is an anionic lipid. The sn-1 and sn-2 positions of the glycerol is esterified with fatty acids. The phosphate group is present in sn-3 position.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. [
Application
15:0-18:1-d7-PI (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoinositol (ammonium salt)) has been used:
as a component of extraction solvent for lipid isolation from biological samples
as an internal standard to spike cell lysate and to quantify lipid species using fourier transform mass spectrometry (FTMS) analysis
as an isotopically labeled lipid internal standard for correction of lipids detected in lipid droplets using shotgun mass spectrometry analysis

Biochem/physiol Actions
Phosphotidylinositol (PI) undergo phosphorylation in their hydroxyls group and the phosphorylated PIs regulate various biological processes including membrane trafficking, endocytosis and autophagy.
Packaging
2 mL Amber Glass Sealed Ampule (791641C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC