Merck, 795682-250MG, (4R,4′R,5S,5′S)-2,2′-(1-Methylethylidene

Application
(4R,4′R,5S,5′S)-2,2′-(1-Methylethylidene) or (4S,5R)-Bis-Phbox) can be used as a ligand:
To prepare selective exo-catalysts for enantioselective 1,3-dipolar cycloaddition reactions.
In the asymmetric aminooxygenation of alkenes in the presence of tetramethylaminopyridyl radical (TEMPO) as an oxidant and copper(II) triflate as a catalyst.
In asymmetric aminofluorination of olefins using an iron catalyst.

This chiral Box ligand was most recently shown to mediate an asymmetric aminofluorination of olefins utlizing Xtalfuor-E (719439) and TREAT-HF (344648). The resulting cyclic carbamates can be readily converted into their concomitant beta-fluoro amino acids.
Other Notes
Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination