Merck, 8.55051, Biotin NovaTag® resin

General description
Biotin NovaTag resin is an ideal tool for the synthesis of peptides labeled with biotin. As the biotin moiety is incorporated into the linker, its use eliminates the problems associated with biotin-labeling of peptides, namely poor solubility and sluggish coupling kinetics of biotin and its derivatives. Following peptide assembly under standard Fmoc SPPS conditions, cleavage with TFA affords the peptide labeled with biotin. For a recent applications see [¹,²].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[¹]M. Carraz, et al. (2009) Chemistry & Biology, 16, 702.
[²] S. Millward, et al. (2007) Chem. Biol., 2, 625.
Analysis Note
Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.35 - 0.65 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer metrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Other Notes
Replaces: 04-12-3901
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany