Description
General description
COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [¹,²].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [³].
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[¹] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
[²] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
[³] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.
Application
Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany