Merck, 8551150005, Aminomethylated polystyrene LL (100-200 mesh)

General description
Novabiochem® AM resin is prepared according to optimized protocols by direct aminomethylation of polystyrene[¹]. This process gives a highly homogeneous and chemically defined support free from potentially reactive chloromethyl groups. This resin can be easily acylated with any appropriate carboxylic acid-containing linker using standard methods of amide bond formation to furnish supports for both Boc and Fmoc batch SPPS and SPOS.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.30 - 0.50 mmol/g
Swelling Volume (in DMF): lot specific result
TNBS-Test (positive): passes test
TNBS-Test (after loading with Fmoc-Leu-OH (negative)): passes test
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Other Notes
Replaces: 01-64-0447
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany