Merck, 90878-250ML-F, Poly(ethylene glycol)

• Development of Lyophilized Eukaryotic Cell-Free Protein Expression System Based on Leishmania tarentolae.: This study explores the use of Poly(ethylene glycol) (PEG) in creating a lyophilized eukaryotic cell-free protein expression system. The research demonstrates how PEG facilitates the stabilization and preservation of cell-free systems, enhancing protein synthesis capabilities for various biochemical applications (Alfaro-Palma et al., 2024).


• High-Contrast Luminescent Immunohistochemistry Using PEGylated Lanthanide Complexes.: The application of PEGylated lanthanide complexes in immunohistochemistry significantly improves the contrast and specificity of luminescent signals. This innovation aids in more accurate biochemical analysis and diagnostics (Su et al., 2022).


• Analyzing Immune Response to Engineered Hydrogels by Hierarchical Clustering of Inflammatory Cell Subsets.: This research investigates the immune responses to PEG-based hydrogels used in tissue engineering. It provides insights into the biocompatibility and inflammatory reactions, essential for designing advanced biomaterials (Fernandez-Yague et al., 2022).


• Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood.: The study shows how PEGylation of nanoparticles affects their interaction with immune cells, influencing drug delivery systems and therapeutic efficacy in biochemistry and molecular biology (Ju et al., 2020).


• A Post-Insertion Strategy for Surface Functionalization of Bacterial and Mammalian Cell-Derived Extracellular Vesicles.: This paper discusses the post-insertion method using PEG for surface functionalization of extracellular vesicles, enhancing their potential for targeted drug delivery and biochemical research (Jiang et al., 2021).

Poly(ethylene glycol) BioUltra 300 is used as a high-purity, low-molecular-weight PEG reagent in biochemical and biomaterials research. This product is a viscous liquid with a relative molecular mass range of 285–315 and the linear formula H(OCH2CH2)nOH. It dissolves in water at 50 mg/mL at 25 °C to form a clear, colorless solution. A 50 mg/mL aqueous solution has a pH of 5.5–7.0 at 25 °C, while the liquid has a density of 1.125 g/mL at 20 °C and a refractive index of 1.465 at 20 °C. Its CAS number is 25322-68-3. Peroxide content does not exceed 0.001% as H2O2; chloride and sulfate each remain at or below 50 mg/kg. UV absorbance remains at or below 0.06 at 260 nm and 0.03 at 280 nm in a 50 mg/mL aqueous solution, supporting applications in which background absorbance and trace contamination matter. The product can be applied in lyophilized eukaryotic cell-free protein-expression systems, PEG-based hydrogel studies, PEGylated luminescent complexes for immunohistochemistry, nanoparticle surface modification, and extracellular-vesicle surface functionalization. Its BioUltra grade, liquid form, water solubility, low peroxide content, and controlled trace-ion profile make it a consistent PEG source for preparing research formulations and reaction systems. The 90878-250ML-F SKU provides 250 mL of PEG 300.