Merck, 912220-1KT, NanoFabTx™ PLGA-micro

General description
The NanoFabTx™ PLGA-micro kit provides reagents (PLGA and stabilizer) and a protocol for microfluidic synthesis of microparticles between 1 to 5 μm. This reagent kit can be combined with the NanoFabTx™ Microfluidic - micro device kit (Cat.No. 911860) for microfluidic synthesis of PLGA micro particles.
Application
NanoFabTx™ PLGA-micro for synthesis of 1-5 μm particle reagent kit is designed for the synthesis of hydrophobic drug- encapsulated poly(lactic-co-glycolic acid) (PLGA) microparticles. The protocol gives users step-by-step instructions developed and tested by our formulation scientists. The protocol includes suggested conditions for incorporating drugs into the formulation and details how to tailor the parameters to yield 1 μm particles, 5 μm particles, or any size in between—all with low polydispersity. This kit affords scientists the synthetic control and reproducibility needed to encapsulate drugs, proteins, or other molecules with polymer microparticles of a chosen size and drug loading. With this kit, researchers can quickly identify the ideal microparticle size and drug loading for their research application. PLGA is a biocompatible and biodegradable polymer that has been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.
Features and Benefits
Flexible synthesis tool to create uniform and reproducible nanoparticles
Optimized to make microparticles 1-5 μm by microfluidics with low polydispersity
Enables microparticle formulation screening and optimization of microparticles 1-5 μm to select ideal particle size for enhanced drug loading and controlled release
Based on non-toxic, biodegradable polymers

Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC