Merck, 914223-5MG, Biotin-SLF

Name: Biotin-SLF
Brand: Merck
SKU: 914223-5MG

Size:5 mg, (R)-3-(3, 4-Dimethoxyphenyl)-1-(3-(4, 18-dioxo-22-((3aS, 4S, 6aR)-2-oxohexahydro-1H-thieno[3, 4-d]imidazol-4-yl)-8, 11, 14-trioxa-5, 17-diazadocosanamido)phenyl)propyl (S)-1-(3, 3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate, Bio-SLF, Biotin-conjugated FKBP12WT-directed ligand, Biotin-conjugated SLF ligand, FKBP12WT affinity probe for PROTAC® and targeted protein degradation research

Catalog Number: 914223-5MG

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Category

Biotin-Conjugated Secondary Antibodies

Pack Size5 mg

TagsChemistry & Biochemicals Chemical Biology Protein Degrader Building Blocks

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Biotin-SLF (bio-SLF) is an FKBP12WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.

Related tools:
Additional bifunctional tools for FKPB12 variants:

dTAG-13 (SML2601) for FKBP12F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Other Notes
The dTAG system for immediate and target-specific protein degradation

Technology Spotlight: Building PROTAC® Degraders for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

General

MDL number	MFCD33021721
UNSPSC Code	12352200
NACRES	NA.22
InChI key	QFIMAWUXIBINCP-SLBVAARVSA-N
SMILES string	O=C(CCC(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@@](N2)([H])[C@]1([H])NC2=O)=O)=O)NC3=CC([C@H](OC([C@@H]4CCCCN4C(C(C(C)(C)CC)=O)=O)=O)CCC5=CC=C(OC)C(OC)=C5)=CC=C3
ligand	biotin
form	powder
storage temp.	−20°C
Quality Level	100

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Merck, 914223-5MG, Biotin-SLF

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