Merck, 914231-50MG, 4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride

Name: 4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride
Brand: Merck
SKU: 914231-50MG

Size:50 mg, DAS1, SFABP, Sulfonyl fluoride activity-based probe, ≥95%

Catalog Number: 914231-50MG

Pricing

Category

Pack Size50 mg

Description

Application
4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride is an alkyne-functionalized sulfonyl fluoride activity-based probe (SFABP). Sulfonyl fluorides covalently modify reactive serines in addition to threonine, lysine, tyrosine, cysteine, and histidine residues in a context-specific manner. Activity-based probes are useful for the targeting, isolation, and identification of proteins. Furtermore, the alkyne handle on SFABP enables click chemistry-based incorpoation of azide tags, such as fluorophores or biotins, for visualization or enrichment and detection, respectively.
Other Notes
Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides

Sulfonyl fluorides as privileged warheads in chemical biology

Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferase

Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases

Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS

Specifications

MDL number	MFCD32857297
UNSPSC Code	12352200
NACRES	NA.22
storage temp.	−20°C
Quality Level	100
InChI key	HWSJGTCAHFQVSV-UHFFFAOYSA-N
InChI	1S/C14H16FNO3S/c1-2-3-4-5-14(17)16-11-10-12-6-8-13(9-7-12)20(15,18)19/h1,6-9H,3-5,10-11H2,(H,16,17)
SMILES string	F[S](=O)(=O)c1ccc(cc1)CCNC(=O)CCCC#C
assay	≥95%
form	powder

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