Description
Application
A1V2PF1-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF1-NHEt is also available as BocA1V2PF1 (916978).
A1V2PF1-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC® degrader libraries: Degrader Building Blocks
916943 A1V2PF1-NHEt-C₆-NH₂
917206 A1V2PF1-NHEt-C₁₀-NH₂
917451 A1V2PF1-NHEt-PEG₁-NH₂
917702 A1V2PF1-NHEt-PEG₃-NH₂
Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
Other Notes
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
SNIPERs−Hijacking IAP activity to induce protein degradation
E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license