Description
General description
NanoFabTx™-DC-Chol Lipid Mix; for synthesis of cationic (DC-cholesterol) liposomes is a ready-to-use nanoformulation blend for the synthesis of liposomes for drug delivery. The NanoFabTx™-DC-Chol Lipid Mix includes optimized protocols with step-by-step instructions for synthesizing cationic DC-cholesterol liposomes for drug delivery applications. The modification of the liposomes with the cationic lipid, DC-cholesterol, have numerous advantages including high gene transfection efficiency. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.
Application
About NanoFabTx™
NanoFabTx™ lipid mixes and formulation kits enable users to encapsulate a wide variety of therapuetic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ reagent kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
Features and Benefits
A ready-to-use nanoformulation blend for the synthesis of cationic DC-cholesterol liposomes
Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
Flexible synthesis tools to create uniform and reproducible liposomes
Optimized to make liposomes around 100 nm with low polydispersity
DC-Cholesterol allows for high transfection efficiency and targeted drug delivery
Comprehensive protocols for liposome synthesis are included:A lipid film hydration and extrusion protocol.
A microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits are ready-to-use and include the microfluidic chip, fittings, and tubing required for microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
