Merck, 930512-50MG, VH 032 amide-PEG3-acid

Name: VH 032 amide-PEG3-acid
Brand: Merck
SKU: 930512-50MG

Size:50 mg, (S, R, S)-AHPC-PEG₃-acid, 3-Dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]ethoxy}propanoic acid, 3-{2 -[2-(2-{[(2S)-1-[(2S, 4R)-4-Hydroxy-2-({[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3, N-[3-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, L-Prolinamide, ≥95.0%

Catalog Number: 930512-50MG

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Category

Carboxylic Acids

Pack Size50 mg

TagsChemistry & Biochemicals Chemical Biology Protein Degrader Building Blocks

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
VH 032 amide-PEG3-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)
Other Notes
Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Specifications

General

UNSPSC Code	12352106
NACRES	NA.21
MDL number	MFCD32693314
InChI key	YHEJFYORSLEJKX-BEYSDYMESA-N
SMILES string	OC(CCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
ligand	VH032
assay	≥95.0%
form	powder
functional group	carboxylic acid
storage temp.	2-8°C
Quality Level	100

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Merck, 930512-50MG, VH 032 amide-PEG3-acid

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