Description
General description
Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.
Application
Non-viral gene delivery applications
Targeted drug delivery applications
Protein coatings and tissue culture
Features and Benefits
Self-assemble capability to form micelles and polymersomes
Amine functional group at the side chain enables further rapid functionalization
Cationic poly(L-lysine) has excellent DNA and RNA condensation property
Biodegradable, biocompatible and water soluble