Description
General description
About this material:
The NanoFabTx™ Phenyl Boronate Functionalized PAMAM Dendrimer is a specialized drug delivery solution developed and tested for efficient protein delivery. This dendrimer exhibits a high binding affinity with a wide range of proteins, thanks to its rich phenylboronic acid (PBA) content. By leveraging the electron-deficient nature of phenyl boronic acid, this dendrimer can effectively coordinate with cationic amine and imidazole groups on proteins, enabling nitrogen-boronate complexations and cationic and ionic interactions. Moreover, the PBA moieties on this NanoFabTx™ dendrimer provide opportunities for self-assembly and effectively address existing barriers in the cytosolic delivery of nucleic acids.
More information including application notes can be found under the "More Documents" tab on this page.
Application
Specifically optimized for intracellular protein delivery, including protein complexes, the NanoFabTx(TM) phenyl boronate functionalized PAMAM dendrimer has applications in:
Therapuetic nuclelic acid and protein delivery - This dendrimer enables the formation of dendrimer-protein complexes thatcan bypass membrane barriers, enable high uptake by mammalian cells, and aid in cysoloic delivery into the cells
Molecular and cell detection: The high density of boronic groups can be used fro molecular and cell detections such as sugar and H₂O₂
Features and Benefits
The NanoFabTx™ drug delivery solutions have been tested to ensure effective therapeutic delivery, and they are accompanied by supported protocols and application notes to guide you on your drug delivery journey. Derived from Sigma-Aldrich Product 536709 (ethylenediamine core, generation 5.0), the NanoFabTx™ phenyl boronate functionalized PAMAM dendrimer offers the following features and benefits:
A ready-to-use formulation for synthesizing dendrimer-protein complexes
Detailed, step-by-step protocols for protein delivery, along with application data for in vitro delivery
A drug delivery solution that enables protein delivery into cells without noticeable toxicity or disruption of metabolism
Flexibility to optimize the material based on protein size and surface properties, providing adaptability for various applications and research needs.
For research use only NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
