Description
General description
PLGA (poly(lactic-co-glycolic acid)) is a biodegradable and biocompatible polymer, FDA-approved for biomedical applications. Upon administration, the PLGA polymer degrades through hydrolysis of its ester backbone into non-toxic byproducts. For drug-loaded particles, the drug molecules are gradually released, and this release rate can be fine-tuned by selecting different types of PLGA and adjusting the encapsulation process.
Factors that influence the degradation and drug release rates include:
Lactide to glycolide (L/G) ratio: a 50:50 L/G ratio exhibits the fastest drug release
Molecular weight: Higher molecular weights result in slower release
Terminal groups: Carboxyl-terminated PLGA polymer provide quicker release compared to ester-terminated PLGA
Application
Degradex® Green Fluorescent PLGA nanoparticles are ideal for a wide range of biomedical and pharmaceutical R&D applications, including:
Controlled drug release: The gradual degradation of PLGA allows for sustained release of encapsulated drug molecules, improving therapeutic efficacy and reducing dosing frequency.
Bioavailability enhancement: PLGA nanoparticles can improve the solubility and stability of poorly water-soluble drugs, enhancing their bioavailability.
Drug targeting: The nanoparticle structure enables targeted drug delivery to specific tissues or cells, potentially reducing side effects and improving treatment outcomes.
API stabilization: Encapsulation in PLGA nanoparticles can protect sensitive active pharmaceutical ingredients (APIs) from degradation.
Drug attachment and delivery: The nanoparticles can act as carriers, allowing drug molecules to be attached to their surface for efficient delivery.
Imaging and cell tracking: Fluorescent nanoparticles can be utilized for imaging, fluid tracing, cell tracking, phagocytosis studies, and fluorescence microscopy. They are particularly effective in drug delivery applications and diagnostic R&D, particularly for detecting binding events or enhancing signals.
Features and Benefits
Degradex Green Fluorescent PLGA nanoparticles are made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a MW of 30,000.
Key Features:
Average diameter: 200nm +/- 30nm
Standard deviation: Gently mix the contents to ensure the particles are well suspended; vortexing or sonication may be necessary.
Nanoparticle size can be measured using analytical methods such as dynamic light scattering (DLS).
Legal Information
Product of Phosphorex, Inc.
Degradex is a registered trademark of Phosphorex, Inc.
