Merck, 999998P-10MG, 06:0 Diether PC

General description
06:0 Diether PC (phosphocholine) is a glycerophospholipid having two hexane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It has choline as the alcohol moiety, attached to the phosphate group.
Application
06:0 Diether PC or 1,2-di-O-hexyl-sn-glycero-3-phosphocholine might be used:
in bicelle media to measure the H—C one-bond residual dipolar couplings for trisaccharides, Lewis X (Lex) and Lewis A (Lea) methyl glycosides using nuclear magnetic resonance (NMR) residual dipolar couplings
to compose isotropically tumbling small bicelles, to study its size and morphology by 31P NMR and atomic force microscopy (AFM)
in bicelle preparation for NMR studies

Biochem/physiol Actions
06:0 Diether PC (phosphocholine) is useful for bicelles preparation. Bicelles can be integrated into standard crystallization protocols and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Incorporating 06:0 Diether PC in bicelles results in bicelles similar to conventional phospholipid bicelles but with improved chemical stability.
Packaging
5 mL Clear Glass Sealed Ampule (999998P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC