Description
General description
1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) is a high-affinity, fast-acting calcium chelator for precise intracellular Ca²⁺ regulation. Its rapid binding kinetics and strong selectivity for Ca²⁺ make it essential for investigating calcium-dependent processes in neuronal and cellular research. BAPTA and its membrane-permeable derivative, BAPTA-AM, allow controlled manipulation of Ca²⁺dynamics, facilitating studies on calcium signaling, neuroprotection, and cell signaling pathways.
Application
The product can be used in various R&D applications such as:
Neuroscience: Used to suppress intracellular Ca²⁺ overload, reduce neuronal apoptosis, and preserve electrophysiological function in injury models, demonstrating strong neuroprotective action.
Pharmacology: Enables precise buffering of intracellular Ca²⁺ levels, allowing researchers to distinguish Ca²⁺‑ dependent drug effects and dissect therapeutic signaling mechanisms.
Other Notes
pKa: 1.401 ± 0.10 (predicted)