Merck, A6419-5G, Adenosine 5′-triphosphate disodium salt hydrate

General description
Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.
Application
Adenosine 5′-triphosphate disodium salt hydrate has been used:
as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
in inflammasome activation assays in bone marrow derived macrophages
for the stimulation of macrophages
in nucleotide synthesis

Biochem/physiol Actions
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems
P2 purinocepter agonist.