Merck, AB9514, Anti-Cholecystokinin A Receptor Antibody

General description
FUNCTION: SwissProt: P32238 # Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SIZE: 428 amino acids; 47841 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P32238 ## Belongs to the G-protein coupled receptor 1 family.
Synthetic peptide from the N-terminal extracellular domain of human Cholecystokinin A Receptor.
Application
Immunohistochemistry on paraffin embedded tissue sections.

Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Recognizes Cholecystokinin A Receptor.
Physical form
Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Preparation Note
Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.