Merck, B352-05, Bovine Pulmonary Artery Smooth Muscle Cells: BPASMC (Cryovial)

General description
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BPASMC have been used in studies relevant to pulmonary hypertension characterized by hyperproliferation of pulmonary artery smooth muscle cells, the process shown to be mediated by hypoxia-induced expression of Bcl-xl (Suzuki, 2007). Additionally, they were used to elucidate the PKC-α dependent mechanisms of proMMP-2 activation and other signaling events in smooth muscle cells under pro-inflammatory conditions related to cell growth (Chakraborti, 2009; Roy, 2011, 2013; Dey, 2012; Chowdhury, 2013; Shaikh, 2013).

Characterization: positive for smooth muscle cell specific alpha-actin expression.
Application
cell growth, signaling, receptor transactivation and suppression, vascular remodeling
Biochem/physiol Actions
Artery
Preparation Note

• 2nd passage, >500,000 cells in Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 16 doublings

Please refer to the BPASMC Culture Protocol.
Other Notes
Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO