Merck, CDS021620-10MG, Fasudil hydrochloride

Name: Fasudil hydrochloride
Brand: Merck
SKU: CDS021620-10MG

Size:10 mg

Catalog Number: CDS021620-10MG

Pricing

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Category

Inhibitors & Activators

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Fasudil hydrochloride is an intracellular calcium channel blocker. It is also a potent vasodilator agent, antihypertensive agent, and protein kinase inhibitor.
Other Notes
Please note that Sigma-Aldrich provides this product to early discovery researchers as part of a collection of unique chemicals. Sigma-Aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.
NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH′S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT "AS-IS" AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY, (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE, OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY, WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	329794883
MDL number	MFCD00943198
NACRES	NA.21
InChI	1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
SMILES string	[H]Cl.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCCNCC3)=O
InChI key	LFVPBERIVUNMGV-UHFFFAOYSA-N
description	AldrichCPR
form	solid

FAQs

Question: What compound and package size are supplied?

Answer:Fasudil hydrochloride, a solid small-molecule research compound, in a 10 mg pack.

Question: What research pathway is commonly investigated with fasudil?

Answer:Rho-associated kinase signaling and related cytoskeletal or contraction responses.

Question: Does the product include a certified assay of purity?

Answer:No product-specific analytical qualification is guaranteed for this Aldrich CPR material; verify identity and purity as required by the research protocol.

Application Note

Sigma-Aldrich fasudil hydrochloride is a small-molecule research compound used in experiments investigating Rho-associated kinase signaling and smooth-muscle contractility. The 10 mg solid package contains the hydrochloride salt of fasudil, a sulfonamide-related kinase inhibitor with a molecular weight of 327.83 g/mol. Research applications can include pharmacological perturbation of ROCK-dependent cytoskeletal signaling, contraction pathways and selected cell-motility models. Effective exposure depends on experimental concentration, treatment duration and cell system, and off-target activity must be considered when attributing biological responses to one kinase. Prepare stock solutions using an experimentally validated solvent and confirm solubility and stability for the chosen method; do not infer a solvent system or working dose from the pack label alone. This Aldrich CPR research product is supplied without routine product-specific analytical characterization, so identity and purity should be independently confirmed when required for quantitative conclusions. It is not a pharmaceutical dosage form and is not suitable for clinical administration.

Ordering

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