Merck, D1530-.1MG, 1α,25-Dihydroxyvitamin D3

Application
1α,25-Dihydroxyvitamin D3 has been used as a supplement:to study its effects on endothelial functions in high glucose-conditioned human umbilical vein endothelial cells (HUVECs)
to study the osteogenic effect of bone morphogenetic protein-2 (BMP2) in human bone marrow-derived mesenchymal stem cells (hMSCs)
in osteogenic differentiation medium for osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs)

Biochem/physiol Actions
Biologically active form of vitamin D₃in calcium absorption and deposition.
Biologically active form of vitamin D₃in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.