Merck, D3071-10UG, Dipeptidyl Peptidase IX human

Name: Dipeptidyl Peptidase IX human
Brand: Merck
SKU: D3071-10UG

Size:10 μg, recombinant, expressed in Sf9 cells

Catalog Number: D3071-10UG

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Category

Dry Ice

Pack Size10 µg

TagsProtein Biology Proteins & Enzymes Proteases

CollectionsMerck Proteins & Enzymes: Nucleases, Albumins & High‑Purity Enzymes Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Full length sequence with an N-terminal GST tag
Application
DPP9 is a protease of the DPP4 gene family that is used in cancer research to study the regulation of survival and proliferation pathways. DPP9 is used to study cell-extracellular matrix interactions and tissue remodeling.
Biochem/physiol Actions
DPP IX is a member of the S9b family of dipeptidyl peptidases and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. It has a role in regulating cell survival and proliferation through modulating molecular signaling cascades. Protein kinase B activation is significantly inhibited by human DPP9 overexpression in human hepatoma cells (HepG2 and Huh7) and human embryonic kidney cells (HEK293T). DPP9 is thought to influence cell-extracellular matrix interactions and may be involved in the regulation of tissue remodeling .
Physical form
Supplied as a solution in 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and 16 mM glutathione
Other Notes
DPP IX is a member of the S9b family of dipeptidyl peptidases. and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV.
One unit will hydrolyze 1.0 picomole of H-Gly-Pro-AMC per minute at pH 7.5 at 25 deg °C

Specifications

General

NACRES	NA.54
UNSPSC Code	12352204
recombinant	expressed in Sf9 cells
form	solution
specific activity	≥250 units/μg protein
shipped in	dry ice
storage temp.	−70°C
Quality Level	200

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Merck, D3071-10UG, Dipeptidyl Peptidase IX human

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