Merck, D5817-25MG, DMXAA

Name: DMXAA
Brand: Merck
SKU: D5817-25MG

Size:25 mg, 5, 6-Dimethylxanthenone-4-acetic Acid, ASA404, Vadimezan, ≥98% (HPLC), solid

Available Catalog Numbers

D5817-25MG D5817-5MG

Catalog Number: D5817-25MG

Pricing

Send an RFQ.

View RFQ List

Category

General Purpose Incubators

Pack Size25 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.
Application
5,6-dimethylxanthenone-4-acetic acid (DMXAA) has been used to induce type-I IFN signaling in a stimulator of interferon genes (STING) dependent manner. It has also been used to study STING-dependent signaling in the absence of infection.
Biochem/physiol Actions
DMXAA is an apoptosis inducer; anti-vascular.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Specifications

General

UNSPSC Code	12352200
PubChem Substance ID	24724464
NACRES	NA.77
Web Name Suffix Override	≥98% (HPLC), solid, apoptosis inducer
MDL number	MFCD00870555
SMILES string	Cc1ccc2C(=O)c3cccc(CC(O)=O)c3Oc2c1C
InChI key	XGOYIMQSIKSOBS-UHFFFAOYSA-N
InChI	1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
assay	≥98% (HPLC)
form	solid
color	light brown
solubility	DMSO: soluble >10 mg/mL
storage temp.	2-8°C
Quality Level	100

FAQs

Question: What is the chemical identity of DMXAA?

Answer:DMXAA is 5,6-dimethylxanthenone-4-acetic acid, also known by the research name vadimezan.

Question: What purity and quantity are supplied?

Answer:This version contains 25 mg of solid DMXAA with a specified assay of at least 98% by HPLC.

Question: Does DMXAA activate STING in all species equally?

Answer:No. Its STING-dependent activity is species sensitive, so experimental results depend on the organism and model used.

Application Note

DMXAA, also known as vadimezan or 5,6-dimethylxanthenone-4-acetic acid, is a small-molecule research compound used to investigate inflammatory signaling and experimental antitumor mechanisms. The solid material has a stated HPLC assay of at least 98% and is supplied in a 25 mg quantity. DMXAA can trigger STING-dependent responses in suitable experimental systems, but its activity is species dependent; results obtained using murine STING must not be assumed to translate directly to human STING models. Select a validated biological system and a concentration range appropriate to the particular endpoint, and include solvent-only controls. The compound dissolves in DMSO, which can be used to prepare a concentrated stock before controlled dilution into assay media. Minimize repeated exposure and follow the specified refrigerated storage conditions for the dry material. This product is an experimental chemical rather than an approved therapeutic agent or a general-purpose cell culture supplement.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.